Barry j marshall wiki
Barry Marshall
Barry James Marshall, AC, FRS, FAA (born 30 September ) is an Australiandoctor and winner of the Nobel Prize in Physiology or Medicine. He is Professor of Clinical Microbiology at the University of Western Australia. Marshall is well known for proving that bacteriaHelicobacter pylori are the cause of most stomach ulcers. This changed years of medical belief which said that ulcers were caused by stress, spicy foods, and too much acid. He took a part-time position at the Pennsylvania State University in [1]
Early years
[change | change source]Marshall was born in Kalgoorlie, Western Australia. He lived in Kalgoorlie and Carnarvon until moving to Perth at the age of seven. He went to high school at Newman College, Perth. At the University of Western Australia, medicine and surgery. He married his wife, Adrienne, in [2] In he was also the Western Australian state yo-yo champion.[2]
Life and research
[change | change source]In Marshall became a Registrar in Medicine at the Royal Perth Hospital. At the hospital he met Robin Warren, a pathologist who was interested in gastritis. They were both training in internal medicine at Royal Perth Hospital in Together they looked at spiral bacteria in gastritis. In they grew a culture of H. pylori. They worked on their idea that there was a bacterial cause of peptic ulcer and stomachcancer.[2] Their idea was laughed at by scientists and doctors who did not believe that any bacteria could live in the acidic stomach. Marshall said that "Everyone was against me, but I knew I was right".[3] Other doctors said they wouldn't believe it until the H. pylori idea could be proved.[4]
Marshall and Warren tried to give the bacteria to piglets in , but it did not work. Marshall drank some of the bacteria and soon developed gastritis with achlorhydria. He had stomach discomfort, nausea, vomiting and bad smelling breath. On the 14th day of the infection, biopsies of Marshall's stomach did not show any bacteria. His body may have got rid of the bacteria without help. His wife made him take antibiotics immediately so there was no way of checking the negative result again. He did not develop antibodies to This means that natural immunity can sometimes get rid of infection. His illness and recovery, showed the link between H. pylori and gastritis, but not for peptic ulcer. This experiment was published in in the Medical Journal of Australia[5] and is among the most cited articles from the journal.[6]
After this work at Fremantle Hospital, Marshall did research at Royal Perth Hospital () and at the University of Virginia, USA (), before going back to Australia. He held a Burnet Fellowship at the University of Western Australia from [7] He is still looking at H. pylori and runs the Research Laboratory at UWA.[8]
Awards and honours
[change | change source]In , the Karolinska Institute in Stockholm gave the Nobel Prize in Physiology or Medicine to Dr. Marshall and Dr. Warren for finding the bacterium Helicobacter pylori and its part in gastritis and peptic ulcer disease.[9]
Marshall was given other awards including:[10]
- Warren Alpert Prize in
- Australian Medical Association Award in
- Albert Lasker Award for Clinical Medical Research in
- Gairdner Foundation International Award in
- Paul Ehrlich and Ludwig Darmstaedter Prize in
- Dr A.H. Heineken Prize for Medicine in
- Florey Medal in
- Buchanan Medal of the Royal Society in
- Benjamin Franklin Medal for Life Sciences in
- Keio Medical Science Prize in
- Australian Centenary Medal in [11]
He was made a Companion of the Order of Australia in [12]
Related pages
[change | change source]Notes
[change | change source]References
[change | change source]- Marshall BJ, Warren JR. Unidentified curved bacillus on gastric epithelium in active chronic gastritis. Lancet ;1() PMID
- Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration. Lancet ;1() PMID
- Sweet, Melissa (2 August ). "Smug as a bug". The Sydney Morning Herald. Archived from the original on Retrieved